Semaneo (semaglutide) injection is a prescription medicine used with a reduced calorie diet and increased physical activity to:

  • Help adults with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems, to lose weight and keep the weight off.
  • Reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or being overweight.
Semaneo Injection

How does Semaneo work?

Appetite and the Brain

Our brain controls hunger and fullness.

In people with overweight or obesity, these signals can become imbalanced, leading to stronger hunger, more cravings, and less satisfaction after meals.

Normally what happens
In obesity

GLP-1 response is weaker

Result: "I'm still hungry" even after eating

Normally what happens:
  1. You eat food
  2. Body releases GLP-1 hormone
  3. GLP-1 tells the brain → "I feel full" ✔
In obesity:
  • GLP-1 response is weaker
  • Result: "I'm still hungry" ✖ even after eating
How Semaneo helps

Semaneo is a GLP-1 receptor agonist (mimics natural GLP-1).

How Semaneo helps

Semaneo is a GLP-1 receptor agonist (mimics natural GLP-1).

It works between your gut and brain to

Reduce appetite
Decrease cravings
Help you feel full sooner and for longer

Why Semaneo ?

Semaneo contains Semaglutide

that offers significant Glycemic control and Weight reduction along with Cardiac and Renal benefits

1.8%
HbA1c Reduction*1
Up to 18.2%
Weight Loss#2
20%
reduction in 3P MACE#3
24%
reduction in major kidney disease events$2
Participants
1961 adults

Adults with BMI ≥30kg/m² and one weight related comorbidity

Duration
68 weeks
Treatment

Semaglutide 2.4 mg + reduced calorie diet

+ increase physical activity

15% (15.8 kg)

weight reduction

1/3

adult achieved 20% weight loss

Dosing

Semaneo dose is once weekly and each pen consists of 4 doses for 4 weeks

After that escalate the dose every 4 weeks

0.25 mg
For 4 weeks
0.5 mg
For 4 weeks Escalation dose
1 mg
For 4 weeks Escalation dose/Maintenance dose for diabetes
1.7 mg
For 4 weeks Escalation dose for obesity
2.4 mg
Recommended Maintenance dose for obesity

Diabetes Therapy

Obesity Therapy

Follow the dose-escalation schedule to reduce the risk of gastrointestinal adverse reactions

Dosing

Start here
0.25 mg
For 4 weeks
›
Escalation dose
0.5 mg
For 4 weeks Escalation dose
›
Escalation dose/Maintenance dose for diabetes
1 mg
For 4 weeks Escalation dose/Maintenance dose for diabetes
›
Escalation dose for obesity
1.7 mg
For 4 weeks Escalation dose for obesity
›
Maintenance dose for obesity
2.4 mg
Recommended Maintenance dose for obesity

Steps to use Semaneo

Prepare for the Injection

Get your supplies together in one place:

  • You‘ll need your Semaneo pen
  • 1 alcohol swab or soap and water
  • 1 gauze pad or cotton ball
  • An FDA-approved sharps container for the used Semaneo pen

Wash your hands

Check your Semaneo pen

Do not use the pen if

  • It appears to have been used
  • Any part appears broken
  • The Semaneo medicine is not clear and colourless through the pen window (air bubbles are normal)
  • The expiration date (EXP) has passed
Steps
Prepare Your Semaneo Pen Needle Setup Choose The Injection Injection Site After Injection
1
Prepare Your Semaneo Pen
  • Check the name and coloured label of your pen to make sure that the pen belongs to the desired dose of Semaglutide. 0.25/0.5/1/1.7/2.4 mg.
  • This is especially important if you take more than one type of injectable medicine. Using the wrong medicine could be harmful to your health.
  • Pull off the pen cap.
  • Check that the solution in your pen is clear and colourless. Look through the pen window.
  • If the solution looks cloudy or coloured, do not use the pen.
  • Take a new needle.
  • Check the paper tab and the outer needle cap for damages that could affect sterility. If any damage is seen, use a new needle.
  • Tear off the paper tab.
  • Do not attach a new needle to your pen until you are ready to take your injection.
  • Make sure to attach the needle correctly.
  • Push the needle straight onto the pen.
  • Turn until it is on tight.
2
Needle Setup
  • The needle is covered by two caps. You must remove both caps. If you forget to remove both caps, you will not inject any solution.
  • Pull off the outer needle cap and keep it for later. You will need it after the injection to safely remove the needle from the pen.
  • Pull off the inner needle cap and throw it away. If you try to put it back on, you may accidentally stick yourself with the needle.
  • A drop of solution may appear at the needle tip. This is normal, but you must still check the flow if you use a new pen for the first time. See step 2 ‘Check the flow with each new pen’.
    Always use a new needle for each injection.
  • This will reduce the risk of contamination, infection, leakage of solution and blocked needles leading to the wrong dose.
  • Do not reuse or share your needles with other people. You may give other people a serious infection or get a serious infection from them.
  • Never use a bent or damaged needle
3
Choose The Injection
  • Your healthcare professional can help you choose the injection site that is best for you
  • You may inject into your upper leg (front of the thigh), lower stomach (keep 2 inches away from your belly button), or upper arm—but make sure you can clearly see the pen window while injecting
  • Do not inject into an area where the skin is tender, bruised, red, or hard. You should also avoid injecting into areas with scars or stretch marks
  • You may inject into the same body area each week, but not in the exact same spot each time
  • Before taking Semaneo, clean your chosen injection site with an alcohol swab or soap and water.
  • Do not touch the injection site after cleaning. Allow the skin to dry before injecting.
4
Inject Site
  • Insert the needle into your skin as your doctor or nurse has shown you.
  • Make sure you can see the dose counter. Do not cover it with your fingers. This could interrupt the injection.
  • Press and hold down the Injection button. Watch as the dose counter returns to ‘0’. The ‘0’ must line up with the dose pointer.
  • Continue pressing the Injection button while keeping the needle in your skin.
  • Count slowly to 6 while keeping the Injection button pressed.
  • If the needle is removed earlier, you may see a stream of solution coming from the needle tip. If so, the full dose will not be delivered.
  • Remove the needle from your skin. You can release the Injection button.
  • If blood appears at the injection site, press lightly with a gauze pad or cotton ball. Do not rub the area.
  • You may see a drop of solution at the needle tip after injecting. This is normal and does not affect your dose.
5
After Injection
  • Carefully remove the needle from the pen. Do not put the needle caps back on the needle to avoid needle sticks.
  • Place the needle in a sharps disposal container right away to reduce the risk of needle sticks.
  • See “Disposing of used Semaglutide pens and needles” below for more information about how to dispose of used pens and needles the right way.

How to store Semaneo pen ?

Before opening

Store your new pen in a refrigerator between 36°F and 46°F (2°C and 8°C). Do not freeze. Keep away from the cooling element. Keep the pen cap on in order to protect it

During use

You can keep the pen for 6 weeks when stored at a temperature below 30°C or in a refrigerator (2°C to 8°C) away from the cooling element. Do not freeze Semaglutide and do not use it if it has been frozen.

When you are not using the pen, keep the pen cap on in order to protect from light.

The pen you are using should be disposed of (thrown away) after 6 weeks, even if it still has Semaglutide in it.

Unused pens may be used unl the expiraon date (“EXP”) printed on the label, if kept in the refrigerator (2°C to 8°C)

What if missed a dose ?

Missed dose

If a dose is missed, it should be administered as soon as possible and within 5 days after the missed dose. If more than 5 days have passed, the missed dose should be skipped, and the next dose should be administered on the regularly scheduled day. In each case, patients can then resume their regular “once weekly dosing” schedule.

Changing the dosing day

The day of weekly administration can be changed if necessary, as long as the time between two doses is at least 3 days (>72 hours). After selecting a new dosing day, once-weekly dosing should be continued

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Important Safety Information

What is the most important information I should know about Semaneo?

Semaneo may cause serious side effects, including:

Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, Semaneo and other medicines that work like Semaneo caused thyroid tumors, including thyroid cancer. It is not known if Semaneo will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people Do not use Semaneo if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Do not use Semaneo if:

you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

you have had a serious allergic reaction to semaglutide or any of the ingredients in Semaneo injection or Semaneo tablets. See symptoms of serious allergic reaction in “What are the possible side effects of Semaneo?”

Before using Semaneo, tell your healthcare provider if you have any other medical conditions, including if you:

have or have had problems with your pancreas or kidneys

have type 2 diabetes and a history of diabetic retinopathy

are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)

are pregnant or plan to become pregnant. Semaneo may harm your unborn baby. You should stop using Semaneo 2 months before you plan to become pregnant

are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with Semaneo tablets. It is not known if Semaneo when received through an injection passes into your breast milk

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Semaneo may affect the way some medicines work and some medicines may affect the way Semaneo works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin. Semaneo slows stomach emptying and can affect medicines that need to pass through the stomach quickly.

What are the possible side effects of Semaneo?

Semaneo may cause serious side effects, including:

inflammation of your pancreas (pancreatitis). Stop using Semaneo and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back

gallbladder problems. Semaneo may cause gallbladder problems, including gallstones. Some gallstones may need surgery. Call your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools

increased risk of low blood sugar (hypoglycemia), especially those who also take medicines for diabetes such as insulin or sulfonylureas. This can be a serious side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar and check your blood sugar before you start and while you take Semaneo. Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery

dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away

severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Semaneo. Tell your healthcare provider if you have stomach problems that are severe or will not go away

serious allergic reactions. Stop using Semaneo and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat

change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Semaneo

increased heart rate. Semaneo can increase your heart rate while you are at rest. Tell your healthcare provider if you feel your heart racing or pounding in your chest and it lasts for several minutes

food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Semaneo may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Semaneo before you are scheduled to have surgery or other procedures

The most common side effects of Semaneo may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, changes in skin sensations, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, heartburn, and hair loss.